Guangzhou Eric Wei Chemical Co., Ltd.
Guangzhou Eric Wei Chemical Co., Ltd.

Ashland Aquasolve L Hydroxypropyl Methylcellulose Acetate Succinate

Ashland Aquasolve L Hydroxypropyl Methylcellulose Acetate Succinate is a pH-dependent, enteric polymer from Ashland’s Aquasolve series—designed for controlled-release oral solid dosage forms. It enhances solubility of poorly water-soluble drugs, remains insoluble in gastric fluid but dissolves rapidly above pH 5.5, and offers excellent film-forming, stability, and regulatory support (FDA DMF, EP/USP monographs).
  • ashland aquasolve l hydroxypropyl methylcellulose acetate succinate_9a4e3bc7
  • ashland aquasolve l hydroxypropyl methylcellulose acetate succinate_9a4e3bc7

Features Of Ashland Aquasolve L Hydroxypropyl Methylcellulose Acetate Succinate

  1. Enteric polymer designed for pH-dependent dissolution in the upper intestine (pH ≥ 5.5).

  2. Enables amorphous solid dispersion stabilization to enhance bioavailability of poorly water-soluble APIs.

  3. Offers excellent film-forming capability and thermoplastic processability for hot-melt extrusion (HME).

  4. Provides robust physical stability and inhibits drug crystallization during storage under accelerated conditions.

  5. Complies with USP/NF, EP, and JP monographs for pharmaceutical excipients.

Typical Applications Of Ashland Aquasolve L Hydroxypropyl Methylcellulose Acetate Succinate

  1. Amorphous solid dispersions (ASDs) for oral solid dosage forms.

  2. Enteric-coated tablets and pellets targeting intestinal release.

  3. Hot-melt extruded (HME) dosage forms requiring thermal stability and melt viscosity control.

  4. Sustained-release matrix systems leveraging pH-responsive solubility behavior.

  5. Stabilizer for nanosuspensions and spray-dried dispersions in preformulation development.

Specifications Of Ashland Aquasolve L Hydroxypropyl Methylcellulose Acetate Succinate

Chemical TypeCellulose derivative — hydroxypropyl methylcellulose acetate succinate (HPMCAS)
Product FormFree-flowing white to off-white granular powder
AppearanceWhite to light tan, free-flowing granules
Primary ApplicationsPharmaceutical solid dispersion carrier, enteric coating agent
Key FeaturespH-dependent solubility, HME-compatible, API stabilization
BenefitsEnhanced solubility & bioavailability, reduced crystallization risk, regulatory compliance
Storage ConditionsStore in original container at 15–30 °C, protect from moisture
Regulatory StatusUSP/NF, EP, JP; DMF on file; compliant with ICH Q5C stability guidelines


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