Guangzhou Eric Wei Chemical Co., Ltd.
Guangzhou Eric Wei Chemical Co., Ltd.

Ashland NATROSOL 250M PHARM Hydroxyethylcellulose

Ashland NATROSOL 250M PHARM Hydroxyethylcellulose is a high-purity, pharmaceutical-grade HEC polymer designed for controlled viscosity and exceptional batch-to-batch consistency. It offers outstanding water solubility, thermal stability, and compatibility with active ingredients—ideal for oral suspensions, topical gels, and ophthalmic formulations requiring USP/NF and EP compliance.
  • ashland natrosol 250m pharm hydroxyethylcellulose_6f0a6ce6
  • ashland natrosol 250m pharm hydroxyethylcellulose_6f0a6ce6

Features Of Ashland NATROSOL 250M PHARM Hydroxyethylcellulose

  1. Pharmaceutical-grade hydroxyethylcellulose (HEC) compliant with USP/NF, EP, and JP monographs for use in oral and topical drug products.

  2. Highly consistent rheology profile with excellent viscosity stability across pH 3–11 and in the presence of electrolytes.

  3. Low microbial bioburden and manufactured under strict cGMP conditions to ensure batch-to-batch reproducibility and regulatory compliance.

  4. Non-ionic, non-irritating, and compatible with a broad range of active pharmaceutical ingredients (APIs) and excipients.

  5. Readily dispersible in cold water with rapid hydration and minimal lump formation when properly dispersed.

Typical Applications Of Ashland NATROSOL 250M PHARM Hydroxyethylcellulose

  1. Viscosity modifier and suspending agent in oral liquid formulations (e.g., syrups, suspensions, and elixirs).

  2. Thickener and film-forming agent in topical gels, creams, and ointments for dermatological and transdermal delivery.

  3. Rheology controller in ophthalmic solutions and gels to enhance residence time and patient comfort.

  4. Stabilizer and binder in immediate-release and modified-release tablet granulations and coatings.

Specifications Of Ashland NATROSOL 250M PHARM Hydroxyethylcellulose

Chemical TypeHydroxyethylcellulose (HEC)
Product FormWhite to off-white free-flowing powder
AppearanceFree-flowing, odorless, fine particulate powder
Primary ApplicationsOral liquids, topical gels, ophthalmic formulations, tablet binders
Key FeaturescGMP-manufactured, USP/NF/EP/JP compliant, low endotoxin, low heavy metals
Viscosity (1% aqueous solution at 25°C)200–300 mPa·s (Brookfield RV, spindle #1, 12 rpm)
Substitution (DS/MS)Molar substitution (MS): 2.2–2.6
Microbial LimitsTotal aerobic count ≤100 CFU/g; absence of E. coli, Salmonella, P. aeruginosa, S. aureus


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