Guangzhou Eric Wei Chemical Co., Ltd.
Guangzhou Eric Wei Chemical Co., Ltd.

Eastman DMF Peptide Grade Dimethylformamide Neutralizer

Eastman DMF Peptide Grade Dimethylformamide Neutralizer is a high-purity, low-amine, neutralized DMF solvent specifically engineered for solid-phase peptide synthesis. It minimizes side reactions, ensures consistent coupling efficiency, and meets stringent USP/EP specifications. Packaged under nitrogen to prevent degradation, it delivers superior batch-to-batch reproducibility and enhanced resin swelling versus standard DMF. Ideal for GMP-compliant peptide manufacturing.
  • eastman dmf peptide grade dimethylformamide neutralizer_4df0d5bb
  • eastman dmf peptide grade dimethylformamide neutralizer_4df0d5bb

Features Of Eastman DMF Peptide Grade Dimethylformamide Neutralizer

  1. Ultra-low residual amine content to minimize side reactions during solid-phase peptide synthesis (SPPS).

  2. Rigorously controlled acidity (pH 6.5–7.5 in aqueous solution) for optimal coupling efficiency and resin stability.

  3. High purity (>99.9% GC assay) with stringent limits on aldehydes, water, and heavy metals per peptide-grade specifications.

  4. Batch-to-batch consistency certified via comprehensive QC testing including NMR, GC-MS, and titration.

  5. Supplied in inert, moisture-barrier packaging to preserve neutralizing capacity and prevent DMF decomposition.

Typical Applications Of Eastman DMF Peptide Grade Dimethylformamide Neutralizer

  1. Solid-phase peptide synthesis (SPPS) as a high-fidelity solvent and neutralizing agent for Fmoc deprotection steps.

  2. Preparation of cGMP-compliant peptide APIs where trace impurity control is critical for regulatory filing.

  3. Use in automated peptide synthesizers requiring consistent solvation power and minimal base-catalyzed racemization.

  4. Research-scale synthesis of complex cyclic and glycopeptides demanding ultra-pure, non-nucleophilic reaction media.

Specifications Of Eastman DMF Peptide Grade Dimethylformamide Neutralizer

Chemical TypeDimethylformamide (DMF) – Neutralized Peptide Grade
Product FormLiquid
AppearanceClear, colorless liquid
pH (10% w/w aqueous solution)6.5 – 7.5
Water Content (KF)≤ 50 ppm
Residual Amines (as dimethylamine)≤ 10 ppm
Aldehyde Content (as formaldehyde)≤ 5 ppm
Heavy Metals (as Pb)≤ 1 ppm


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