Highly uniform particle size distribution for consistent flow and compression behavior.
Optimized crystallinity and surface area to enhance binder efficiency in direct compression formulations.
Low moisture content (< 5.0%) ensuring excellent stability and reduced risk of hydrolysis in moisture-sensitive APIs.
Free-flowing, non-hygroscopic powder with superior bulk density for reliable hopper feeding in high-speed tablet presses.
Pharmaceutical-grade purity compliant with USP/NF, EP, and JP monographs for microcrystalline cellulose.
Direct compression excipient in oral solid dosage forms (tablets and capsules).
Binder and filler in immediate-release and modified-release tablet formulations.
Stabilizer and bulking agent in lyophilized biopharmaceutical products.
Matrix former in controlled-release oral tablets requiring robust mechanical integrity.
Functional additive in nutraceutical and dietary supplement tablets for improved manufacturability.
| Chemical Type | Microcrystalline cellulose (MCC) |
| Product Form | Free-flowing white to off-white granular powder |
| Appearance | Odorless, tasteless, fine granules |
| Primary Applications | Pharmaceutical direct compression, nutraceutical tablets, lyophilization support |
| Key Features | High compressibility, excellent flowability, low moisture content |
| Compliance | USP/NF, Ph. Eur., JP, FDA GRAS, ISO 9001 certified manufacturing |
| pH (5% aqueous suspension) | 5.0 – 7.5 |
| Residue on Ignition | ≤ 0.3% |
Q1: What are the key functional advantages of CEOLUS KG1000 compared to standard microcrystalline cellulose grades?
A: CEOLUS KG1000 is engineered for superior compressibility and binder efficiency in direct compression tablet formulations. Its unique particle morphology—featuring high sphericity and narrow particle size distribution—enables improved flow, enhanced densification at lower compaction pressures, and more consistent tablet hardness and disintegration performance.
Q2: Is CEOLUS KG1000 suitable for use in pharmaceutical applications requiring high purity and low endotoxin levels?
A: Yes, CEOLUS KG1000 is manufactured under strict quality control conditions and complies with major pharmacopoeial requirements for microcrystalline cellulose, including USP-NF and Ph. Eur. It is produced using purified wood pulp and undergoes validated purification processes to ensure low microbial burden and minimal endotoxin content, supporting its use in oral solid dosage forms.
Q3: How does CEOLUS KG1000 perform in combination with highly potent or low-dose active pharmaceutical ingredients (APIs)?
A: Due to its excellent flowability and uniform particle packing, CEOLUS KG1000 supports robust content uniformity in low-dose formulations. Its high surface area and binding capacity allow effective dispersion and stabilization of APIs during blending and compression, reducing segregation risk without requiring additional glidants or lubricants in many cases.
Q4: Can CEOLUS KG1000 be used in non-pharmaceutical applications such as food or nutraceutical tablets?
A: Yes, CEOLUS KG1000 meets relevant food-grade specifications and is widely applied in functional food bars, chewable supplements, and lozenges where clean-label functionality, rapid disintegration, and texture control are required. Its neutral taste, low moisture content, and compatibility with common excipients make it well-suited for these applications.
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