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Ashland Aqualon EC T10 is a high-quality low-viscosity ethyl cellulose in the Aqualon series. Custom-designed for sustained-release coating, matrix molding of oral solid dosage forms and multi-particulate formulations, it meets stringent international pharmacopoeia standards, featuring excellent solubility in organic solvents
Precise Controlled-Release Regulation - Water-insoluble film-forming feature, flexibly regulating drug release rate for long-acting administration
Broad Solvent Compatibility - Easily soluble in various polar organic solvents, suitable for diverse coating and formulation systems
Flexible Film-Forming Protection - Forms tough and transparent films with wide temperature adaptability, enhancing formulation stability and appearance
pH Stable Adaptation - Non-ionic feature, pH insensitive, ensuring stable drug release in different gastrointestinal environments
Formulation Sustained-Release Coating - Used for sustained-release coating of tablets and pellets to achieve long-acting and stable drug release
Controlled-Release Matrix Formulations - Used as matrix material to prepare sustained-release tablets, precisely regulating drug release profile
Multi-Particulate Delivery Systems - Used for coating of pellets and granules to construct multi-unit controlled-release delivery systems
Tablet Binding & Granulation - Used as binder in granulation of hydrophobic drug tablets to improve particle stability
| Brand | Ashland (USA) |
| Chemical Type | Ethyl Cellulose (EC), non-ionic cellulose ether |
| Physical Form | White to off-white free-flowing powder |
| Core Characteristics | Low viscosity, excellent solubility in organic solvents, water-insoluble |
| CAS Number | 9004-57-3 |
| Weight-Average Molecular Weight | 75,000 |
| Viscosity (5% Toluene/Ethanol 80/20 solution) | 8 - 11 mPa·s |
| Ethoxy Substitution Degree | 49.6 - 51.0 % |
Q1: What are the primary functional roles of Aqualon EC T10 in pharmaceutical and coating formulations?
A: Aqualon EC T10 serves primarily as a film-forming agent, binder, and viscosity modifier. It provides robust, water-insoluble films with good mechanical strength and controlled release characteristics, making it especially suitable for enteric and sustained-release oral dosage forms.
Q2: How does EC T10 differ from other ethyl cellulose grades like EC N10 or EC E10?
A: EC T10 is distinguished by its specific viscosity profile and particle morphology—optimized for rapid dispersion and consistent film formation in aqueous-based coating systems. Compared to standard grades, it offers enhanced batch-to-batch reproducibility and improved compatibility with common plasticizers and pigments used in pharmaceutical film coatings.
Q3: Is Aqualon EC T10 compatible with common pharmaceutical plasticizers such as triethyl citrate or dibutyl sebacate?
A: Yes, EC T10 demonstrates excellent compatibility with widely used non-phthalate plasticizers. It forms homogeneous, flexible films when blended with agents like triethyl citrate, ensuring reliable performance across various coating processes including pan coating and fluidized bed application.
Q4: Can EC T10 be used in solvent-based versus aqueous coating systems?
A: EC T10 is fully soluble in common organic solvents (e.g., ethanol, acetone, isopropanol) and is also readily dispersible in aqueous systems when formulated with appropriate surfactants or stabilizers. Its versatility supports both traditional solvent-based and modern aqueous-based coating operations.
Q5: What storage conditions are recommended to maintain optimal performance of EC T10?
A: Store in a cool, dry place in original sealed packaging. Avoid exposure to excessive humidity and temperature fluctuations, as moisture uptake may affect dispersibility and film uniformity during processing.
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