Guangzhou Eric Wei Chemical Co., Ltd.
Guangzhou Eric Wei Chemical Co., Ltd.

Ashland Aquasolve HPMCAS Grade H Hydroxypropyl Methylcellulose Acetate Succinate

Ashland Aquasolve HPMCAS Grade H is a high-quality cellulosic polymer in the Aquasolve series. Custom-designed for solid dispersion preparation of poorly soluble drugs and enteric coating of oral formulations, it features unique amphiphilicity and high glass transition temperature, forming uniform and stable films, which can significantly improve drug solubility and bioavailability

Features Of Ashland Aquasolve HPMCAS Grade H Hydroxypropyl Methylcellulose Acetate Succinate

  1. Efficient Solubilization Enhancement - Adapts to solubilization needs of poorly soluble drugs, improving drug solubility and bioavailability

  2. Precise Enteric Regulation - pH-dependent drug release feature, avoiding drug release in the stomach and ensuring intestinal targeted efficacy

  3. Excellent Film-Forming Protection - Uniform and dense film formation with moisture-proof and oxygen-barrier functions, enhancing formulation storage stability

  4. Spray Drying Adaptation - Low viscosity suitable for spray drying process, ensuring molding quality of solid dispersions

Typical Applications Of Ashland Aquasolve HPMCAS Grade H Hydroxypropyl Methylcellulose Acetate Succinate

  1. Solid Dispersion Preparation - Used as polymer carrier for preparing solid dispersions of poorly soluble drugs by spray drying

  2. Oral Enteric Coating - Used for enteric film coating of tablets and capsules to achieve intestinal targeted drug release

  3. Sustained-Release Granule Formulation - Combined with other excipients to prepare pH-dependent sustained-release granules

  4. Capsule Filling Excipient - Used in capsule filling systems to improve filling uniformity of poorly soluble drugs

Specifications Of Ashland Aquasolve HPMCAS Grade H Hydroxypropyl Methylcellulose Acetate Succinate

Chemical TypeHydroxypropyl Methylcellulose Acetate Succinate (HPMCAS), cellulosic polymer
Physical FormWhite to off-white powder, slightly acetic odor or odorless
Core CharacteristicsAmphiphilic, high glass transition temperature, low viscosity, pH-dependent drug release
CAS Number71138-97-1
Weight-Average Molecular Weight75,100
Nominal Viscosity (Test method: NF/EP/JP)2.4 - 3.6 mPa·s
Degree of SubstitutionAcetyl content 10-14%, Succinyl content 4-8%, Methoxyl content 12-18%, Hydroxypropoxyl content 4-23%


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