Ashland Aquasolve HPMCAS Grade M is a high-quality cellulosic polymer in the Aquasolve series. Custom-designed for solid dispersion preparation of poorly soluble drugs and enteric coating of oral formulations, it features balanced amphiphilicity and high glass transition temperature, forming uniform and stable films. It significantly improves drug solubility and bioavailability
Balanced Solubilization Adaptation - Adapts to solubilization of various poorly soluble drugs, efficiently improving drug solubility and bioavailability
Precise Enteric Regulation - Medium pH-dependent drug release feature, avoiding drug degradation in the stomach and ensuring intestinal targeted efficacy
Excellent Film-Forming Protection - Dense and flexible film formation with moisture-proof and oxygen-barrier functions, enhancing formulation storage and transportation stability
Diverse Process Compatibility - Low viscosity suitable for complex processes like spray drying and hot-melt extrusion, ensuring molding quality
Solid Dispersion Preparation - Used as polymer carrier for preparing solid dispersions of poorly soluble drugs by spray drying
Oral Enteric Coating - Used for enteric film coating of tablets and capsules to achieve intestinal targeted drug release
Sustained-Release Granule Formulation - Combined with other excipients to prepare pH-dependent sustained-release granule formulations
Capsule Filling Excipient - Used in capsule filling systems to improve filling uniformity and stability of poorly soluble drugs
| Chemical Type | Hydroxypropyl Methylcellulose Acetate Succinate (HPMCAS), cellulosic polymer |
| Physical Form | White to off-white powder, slightly acetic odor or odorless |
| Core Characteristics | Amphiphilic, high glass transition temperature, low viscosity, pH-dependent drug release |
| CAS Number | 71138-97-1 |
| Weight-Average Molecular Weight | 75,100 |
| Nominal Viscosity (Test method: NF/EP/JP) | 2.4 - 3.6 mPa·s |
| Degree of Substitution | Acetyl content 10-14%, Succinyl content 4-8%, Methoxyl content 12-18%, Hydroxypropoxyl content 4-23% |
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