Guangzhou Eric Wei Chemical Co., Ltd.
Guangzhou Eric Wei Chemical Co., Ltd.

Ashland Aquasolve HPMCAS Grade M Hydroxypropyl Methylcellulose Acetate Succinate

Ashland Aquasolve HPMCAS Grade M is a high-quality cellulosic polymer in the Aquasolve series. Custom-designed for solid dispersion preparation of poorly soluble drugs and enteric coating of oral formulations, it features balanced amphiphilicity and high glass transition temperature, forming uniform and stable films. It significantly improves drug solubility and bioavailability

Features Of Ashland Aquasolve HPMCAS Grade M Hydroxypropyl Methylcellulose Acetate Succinate

  1. Balanced Solubilization Adaptation - Adapts to solubilization of various poorly soluble drugs, efficiently improving drug solubility and bioavailability

  2. Precise Enteric Regulation - Medium pH-dependent drug release feature, avoiding drug degradation in the stomach and ensuring intestinal targeted efficacy

  3. Excellent Film-Forming Protection - Dense and flexible film formation with moisture-proof and oxygen-barrier functions, enhancing formulation storage and transportation stability

  4. Diverse Process Compatibility - Low viscosity suitable for complex processes like spray drying and hot-melt extrusion, ensuring molding quality

Typical Applications Of Ashland Aquasolve HPMCAS Grade M Hydroxypropyl Methylcellulose Acetate Succinate

  1. Solid Dispersion Preparation - Used as polymer carrier for preparing solid dispersions of poorly soluble drugs by spray drying

  2. Oral Enteric Coating - Used for enteric film coating of tablets and capsules to achieve intestinal targeted drug release

  3. Sustained-Release Granule Formulation - Combined with other excipients to prepare pH-dependent sustained-release granule formulations

  4. Capsule Filling Excipient - Used in capsule filling systems to improve filling uniformity and stability of poorly soluble drugs

Specifications Of Ashland Aquasolve HPMCAS Grade M Hydroxypropyl Methylcellulose Acetate Succinate

Chemical TypeHydroxypropyl Methylcellulose Acetate Succinate (HPMCAS), cellulosic polymer
Physical FormWhite to off-white powder, slightly acetic odor or odorless
Core CharacteristicsAmphiphilic, high glass transition temperature, low viscosity, pH-dependent drug release
CAS Number71138-97-1
Weight-Average Molecular Weight75,100
Nominal Viscosity (Test method: NF/EP/JP)2.4 - 3.6 mPa·s
Degree of SubstitutionAcetyl content 10-14%, Succinyl content 4-8%, Methoxyl content 12-18%, Hydroxypropoxyl content 4-23%


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