Ashland Aquasolve HPMCAS L is a high-quality enteric cellulosic polymer in the Aquasolve series. Custom-designed for solid dispersion preparation of poorly soluble drugs, enteric coating of oral formulations and intestinal targeted delivery systems, it meets stringent international pharmacopoeia standards, featuring pH-dependent solubility and tough film-forming
pH-Dependent Solubility - Insoluble in gastric acid environment, rapidly swells and dissolves in small intestine, achieving intestinal targeted release
Bioavailability Enhancement - As solid dispersion carrier, significantly improves solubility of poorly soluble drugs
Tough Film-Forming Protection - Forms dense and flexible films, blocking gastric acid erosion and ensuring drug stability
Excellent Processing Adaptation - Suitable for aqueous dispersion coating, organic solvent coating and other processes with good flowability
Solid Dispersion Preparation - Used as carrier for solid dispersion of poorly soluble drugs to improve drug dissolution rate
Formulation Enteric Coating - Used for enteric coating of tablets and capsules to achieve intestinal targeted drug release
Intestinal Targeted Formulations - Constructs intestinal targeted delivery systems, protecting bioactive drugs from gastric acid damage
Sustained-Release Matrix - Used as matrix material for sustained-release formulations to regulate stable drug release in intestines
| Brand | Ashland (USA) |
| Chemical Type | Hydroxypropyl Methylcellulose Acetate Succinate (HPMCAS), non-ionic cellulosic ether ester |
| Physical Form | White to off-white free-flowing powder, with faint acetic acid-like odor |
| Core Characteristics | pH-dependent solubility, enteric solubility, bioavailability enhancement, tough film-forming |
| CAS Number | 71138-97-1 |
| Weight-Average Molecular Weight | 114,700 |
| Nominal Viscosity | 2.4 - 3.6 mPa·s |
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