Ashland Aquasolve HPMCAS L Hydroxypropyl Methylcellulose Acetate Succinate

Features Of Ashland Aquasolve HPMCAS L Hydroxypropyl Methylcellulose Acetate Succinate

1. pH-Dependent Solubility - Insoluble in gastric acid environment, rapidly swells and dissolves in small intestine, achieving intestinal targeted release

2. Bioavailability Enhancement - As solid dispersion carrier, significantly improves solubility of poorly soluble drugs

3. Tough Film-Forming Protection - Forms dense and flexible films, blocking gastric acid erosion and ensuring drug stability

4. Excellent Processing Adaptation - Suitable for aqueous dispersion coating, organic solvent coating and other processes with good flowability

Typical Applications Of Ashland Aquasolve HPMCAS L Hydroxypropyl Methylcellulose Acetate Succinate

1. Solid Dispersion Preparation - Used as carrier for solid dispersion of poorly soluble drugs to improve drug dissolution rate

2. Formulation Enteric Coating - Used for enteric coating of tablets and capsules to achieve intestinal targeted drug release

3. Intestinal Targeted Formulations - Constructs intestinal targeted delivery systems, protecting bioactive drugs from gastric acid damage

4. Sustained-Release Matrix - Used as matrix material for sustained-release formulations to regulate stable drug release in intestines

Specifications Of Ashland Aquasolve HPMCAS L Hydroxypropyl Methylcellulose Acetate Succinate

Ashland Aquasolve HPMCAS L Hydroxypropyl Methylcellulose Acetate Succinate – Frequently Asked Questions (FAQ)

Q1: What is the primary functional role of Aquasolve HPMCAS L in pharmaceutical formulations?

A: Aquasolve HPMCAS L is primarily used as a pH-dependent enteric polymer to enable targeted drug release in the intestine. It remains insoluble in gastric fluid but dissolves rapidly at higher intestinal pH, protecting acid-labile APIs and supporting controlled or delayed release profiles in solid oral dosage forms such as tablets and capsules.

Q2: How does Aquasolve HPMCAS L differ from other HPMCAS grades (e.g., MG or HG)?

A: Aquasolve HPMCAS L is the low-substituted grade, characterized by relatively lower acetyl and succinyl substitution levels compared to medium (MG) or high (HG) grades. This results in higher aqueous solubility onset pH and slower dissolution kinetics, making it especially suitable for formulations requiring more gradual or robust enteric protection in the proximal small intestine.

Q3: Is Aquasolve HPMCAS L compatible with common spray-drying and hot-melt extrusion processes?

A: Yes — Aquasolve HPMCAS L is widely used in both spray-dried dispersion (SDD) and hot-melt extrusion (HME) applications. Its thermal stability and solubility profile support efficient amorphous solid dispersion formation, helping to enhance the solubility and bioavailability of poorly water-soluble active pharmaceutical ingredients.

Q4: What are typical handling and storage recommendations for this polymer?

A: Store in original unopened containers under cool, dry conditions, protected from moisture and direct sunlight. Due to its hygroscopic nature, minimize exposure to ambient humidity during handling. Pre-conditioning may be advisable prior to processing in low-humidity environments to ensure consistent flow and dispersion behavior.