Guangzhou Eric Wei Chemical Co., Ltd.
Guangzhou Eric Wei Chemical Co., Ltd.

Ashland Aquasolve HPMCAS L Hydroxypropyl Methylcellulose Acetate Succinate

Ashland Aquasolve HPMCAS L is a high-quality enteric cellulosic polymer in the Aquasolve series. Custom-designed for solid dispersion preparation of poorly soluble drugs, enteric coating of oral formulations and intestinal targeted delivery systems, it meets stringent international pharmacopoeia standards, featuring pH-dependent solubility and tough film-forming

Features Of Ashland Aquasolve HPMCAS L Hydroxypropyl Methylcellulose Acetate Succinate

  1. pH-Dependent Solubility - Insoluble in gastric acid environment, rapidly swells and dissolves in small intestine, achieving intestinal targeted release

  2. Bioavailability Enhancement - As solid dispersion carrier, significantly improves solubility of poorly soluble drugs

  3. Tough Film-Forming Protection - Forms dense and flexible films, blocking gastric acid erosion and ensuring drug stability

  4. Excellent Processing Adaptation - Suitable for aqueous dispersion coating, organic solvent coating and other processes with good flowability

Typical Applications Of Ashland Aquasolve HPMCAS L Hydroxypropyl Methylcellulose Acetate Succinate

  1. Solid Dispersion Preparation - Used as carrier for solid dispersion of poorly soluble drugs to improve drug dissolution rate

  2. Formulation Enteric Coating - Used for enteric coating of tablets and capsules to achieve intestinal targeted drug release

  3. Intestinal Targeted Formulations - Constructs intestinal targeted delivery systems, protecting bioactive drugs from gastric acid damage

  4. Sustained-Release Matrix - Used as matrix material for sustained-release formulations to regulate stable drug release in intestines

Specifications Of Ashland Aquasolve HPMCAS L Hydroxypropyl Methylcellulose Acetate Succinate

BrandAshland (USA)
Chemical TypeHydroxypropyl Methylcellulose Acetate Succinate (HPMCAS), non-ionic cellulosic ether ester
Physical FormWhite to off-white free-flowing powder, with faint acetic acid-like odor
Core CharacteristicspH-dependent solubility, enteric solubility, bioavailability enhancement, tough film-forming
CAS Number71138-97-1
Weight-Average Molecular Weight114,700
Nominal Viscosity2.4 - 3.6 mPa·s


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