Guangzhou Eric Wei Chemical Co., Ltd.
Guangzhou Eric Wei Chemical Co., Ltd.

Ashland Aquasolve M Hydroxypropyl Methylcellulose Acetate Succinate

Ashland Aquasolve M Hydroxypropyl Methylcellulose Acetate Succinate is a pH-responsive, film-forming polymer designed for enteric-controlled drug delivery. It dissolves above pH 5.5, enabling targeted intestinal release while resisting gastric degradation. This grade offers excellent solubility, stability, and compatibility with common pharmaceutical excipients and APIs.
  • ashland aquasolve m hydroxypropyl methylcellulose acetate succinate_89e97967
  • ashland aquasolve m hydroxypropyl methylcellulose acetate succinate_89e97967

Features Of Ashland Aquasolve M Hydroxypropyl Methylcellulose Acetate Succinate

  1. Enteric polymer that dissolves only at pH ≥ 5.5, enabling targeted intestinal drug release.

  2. Excellent film-forming capability for robust enteric coating of oral solid dosage forms.

  3. Good solubility in common organic solvents (e.g., acetone, ethanol, isopropanol) and water-miscible co-solvent systems.

  4. Thermally stable with low moisture sensitivity, supporting consistent processing during fluid-bed or pan coating.

  5. Complies with major pharmacopoeial standards including USP/NF and EP monographs for HPMCAS.

Typical Applications Of Ashland Aquasolve M Hydroxypropyl Methylcellulose Acetate Succinate

  1. Enteric coating for tablets and capsules to prevent gastric degradation of acid-labile APIs.

  2. Amorphous solid dispersion (ASD) carrier to enhance solubility and bioavailability of poorly water-soluble drugs.

  3. Stabilizer and matrix former in hot-melt extrusion (HME) formulations.

  4. Functional excipient in controlled-release multiparticulate systems (e.g., pellets, granules).

  5. Coating agent for functional food and nutraceutical delivery systems requiring pH-triggered release.

Specifications Of Ashland Aquasolve M Hydroxypropyl Methylcellulose Acetate Succinate

Chemical TypeHydroxypropyl methylcellulose acetate succinate (HPMCAS)
Product FormFree-flowing white to off-white powder
AppearanceWhite to light tan, odorless, free-flowing powder
Primary ApplicationsEnteric coating, amorphous solid dispersions, controlled-release formulations
Key FeaturespH-dependent solubility, film-forming, thermoplastic behavior, regulatory-compliant
BenefitsImproved API stability, enhanced dissolution performance, scalable manufacturing compatibility
Regulatory StatusUSP/NF, Ph. Eur., JP listed; DMF available
Storage ConditionsStore in original container at 15–30 °C, protect from moisture


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