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Ashland Benecel HPMC 2208K K250 is a high-quality low viscosity water-soluble hydroxypropyl methylcellulose polymer in the Benecel 2208K series. Custom-designed for oral solid dosage form binding-granulation, film coating and conventional tablet molding, it meets stringent international pharmacopoeia standards, with excellent water solubility
Low Viscosity & Easy Dissolution - Rapid dissolution without agglomeration, suitable for high-concentration formulations and fast granulation
Uniform Film-Forming Protection - Smooth and dense film formation, improving tablet appearance texture and enhancing moisture-proof performance
Mild Binding Enhancement - Excellent binding performance, ensuring particle formability and flowability, reducing tableting loss
Multi-National Pharmacopoeia Compliance - Meets USP/EP/JP standards, high-purity pharm-grade quality, safe and reliable to use
Formulation Binding & Granulation - Used as binder in tablet wet granulation and dry granulation to improve particle uniformity
Pharmaceutical Film Coating - Used as film coating material for oral tablets to optimize appearance and protection performance
Conventional Tablet Molding - Used for conventional oral tablet preparation to ensure tablet molding stability
Capsule Filling Excipient - Used as glidant in capsule filling systems to improve filling efficiency and uniformity
| Brand | Ashland (USA) |
| Chemical Type | Hydroxypropyl Methylcellulose (HPMC) Type 2208,non-ionic cellulose ether |
| Physical Form | White to off-white free-flowing powder |
| Core Characteristics | Low viscosity,Water-soluble,Easy dissolution,Uniform film formation |
| CAS Number | 9004-65-3 |
| Weight-Average Molecular Weight | 200,000 |
| Viscosity (mPa·s) | 200-300(2% aqueous solution, 20℃) |
| Degree of Substitution | Methoxyl content 19.0-24.0%,Hydroxypropoxyl content 4.0-12.0% |
Q1: What is the primary functional role of Benecel HPMC 2208K K250 in formulations?
A: Benecel HPMC 2208K K250 functions primarily as a water-soluble thickener and rheology modifier, providing viscosity enhancement, suspension stability, and improved film-forming capability in aqueous systems.
Q2: How does this grade differ from other Benecel HPMC products?
A: The 2208K K250 designation indicates a specific combination of hydroxypropyl methylcellulose (HPMC) substitution pattern and controlled molecular weight distribution, optimized for balanced solubility, gel temperature profile, and shear-thinning behavior—particularly suited for applications requiring moderate thermal gelation and robust solution clarity.
Q3: Is Benecel HPMC 2208K K250 compatible with common preservatives and electrolytes?
A: Yes, it demonstrates good compatibility with widely used cosmetic and pharmaceutical preservatives (e.g., parabens, phenoxyethanol) and low-to-moderate concentrations of electrolytes, though high ionic strength may reduce viscosity—formulation testing is recommended for critical applications.
Q4: What are typical handling and dissolution considerations for this grade?
A: For optimal dispersion and to avoid lumping, gradual addition with high-shear mixing into cold water is recommended. Pre-wetting with a water-miscible solvent (e.g., propylene glycol or ethanol) can further aid uniform hydration, especially in high-viscosity or low-water formulations.
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