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Ashland Klucel HPC ELF is a high-quality ultra-low molecular weight hydroxypropyl cellulose polymer in the Klucel series. Custom-designed for immediate-release molding, efficient binding of oral solid dosage forms and multi-solvent system formulations, it meets stringent international pharmacopoeia standards
Water-Oil Dual Solubility Adaptation - Both water and organic solvent soluble, suitable for diverse formulation systems
Rapid Dissolution Enhancement - Ultra-low molecular weight enables rapid dissolution without agglomeration, meeting immediate-release requirements
Efficient Binding & Molding - Excellent binding performance, ensuring uniform particle formation and enhancing tablet hardness stability
Multi-National Pharmacopoeia Compliance - Meets USP/EP/JP standards, high-purity pharm-grade quality, safe and reliable to use
Immediate-Release Tablet Preparation - Used for molding and binding of oral immediate-release tablets to ensure rapid dissolution and efficacy
Multi-Solvent Formulations - Used in water-oil mixed system formulations to improve formulation compatibility and stability
Wet Granulation Binding - Used as binder in tablet wet granulation to improve particle flowability and uniformity
Capsule Filling Excipient - Used as glidant in capsule filling systems to optimize filling efficiency and content uniformity
| Product Model | Klucel™ Hydroxypropyl Cellulose (HPC) ELF |
| Brand | Ashland (USA) |
| Chemical Type | Hydroxypropyl Cellulose (HPC), non-ionic cellulose ether |
| Physical Form | White to off-white free-flowing powder |
| Core Characteristics | Ultra-low molecular weight, water-oil dual solubility, rapid dissolution |
| CAS Number | 9004-64-2 |
| Weight-Average Molecular Weight | 40,000 |
| Viscosity (10% aqueous solution, Brookfield) | 150 - 225 mPa·s |
| Pharmacopoeia Standard | Complies with United States Pharmacopeia (USP) |
Q1: What distinguishes Klucel HPC ELF from other hydroxypropyl cellulose grades?
A: Klucel HPC ELF is an ultra-low-viscosity, highly purified grade of hydroxypropyl cellulose specifically engineered for sensitive applications such as ophthalmic formulations and injectables. It offers rapid hydration, excellent clarity in solution, and minimal gelation tendency compared to higher-viscosity HPC variants.
Q2: Is Klucel HPC ELF suitable for parenteral or ophthalmic use?
A: Yes — Klucel HPC ELF is manufactured under stringent pharmaceutical-grade controls and is widely used as a viscosity modifier and stabilizer in sterile ophthalmic solutions and select parenteral formulations, subject to appropriate regulatory qualification by the end user.
Q3: How does Klucel HPC ELF perform in aqueous systems with electrolytes or varying pH?
A: Klucel HPC ELF demonstrates good compatibility with common physiological electrolytes and maintains solution clarity and viscosity stability across a broad pH range (approximately 3–11), though performance may vary depending on specific ionic strength and formulation composition.
Q4: What are typical dosage levels when using Klucel HPC ELF in topical or ophthalmic formulations?
A: Dosage depends on the desired rheological profile and functional requirements, but Klucel HPC ELF is typically used at low concentrations — generally ranging from 0.1% to 2% by weight — to achieve effective thickening or suspension stabilization without compromising clarity or syringeability.
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