English
Español
tiếng việt
русский
Ashland Klucel HPC LF is a high-quality low-molecular-weight hydroxypropyl cellulose polymer in the Klucel series. Custom-designed for binding granulation, film coating of oral solid dosage forms and multi-solvent system formulations, it meets stringent international pharmacopoeia standards, featuring water-oil dual solubility
Water-Oil Dual Solubility Adaptation - Both water and organic solvent soluble, suitable for diverse formulation systems
Rapid Dissolution Enhancement - Ultra-low molecular weight enables rapid dissolution without agglomeration, meeting immediate-release requirements
Efficient Binding & Molding - Excellent binding performance, ensuring uniform particle formation and enhancing tablet hardness stability
Multi-National Pharmacopoeia Compliance - Meets USP/EP/JP standards, high-purity pharm-grade quality, safe and reliable to use
Immediate-Release Tablet Preparation - Used for molding and binding of oral immediate-release tablets to ensure rapid dissolution and efficacy
Multi-Solvent Formulations - Used in water-oil mixed system formulations to improve formulation compatibility and stability
Wet Granulation Binding - Used as binder in tablet wet granulation to improve particle flowability and uniformity
Capsule Filling Excipient - Used as glidant in capsule filling systems to optimize filling efficiency and content uniformity
| Product Model | Klucel™ Hydroxypropyl Cellulose (HPC) ELF |
| Brand | Ashland (USA) |
| Chemical Type | Hydroxypropyl Cellulose (HPC), non-ionic cellulose ether |
| Physical Form | White to off-white free-flowing powder |
| Core Characteristics | Ultra-low molecular weight, water-oil dual solubility, rapid dissolution |
| CAS Number | 9004-64-2 |
| Weight-Average Molecular Weight | 40,000 |
| Viscosity (10% aqueous solution, Brookfield) | 150 - 225 mPa·s |
| Pharmacopoeia Standard | Complies with United States Pharmacopeia (USP) |
Q1: What distinguishes Klucel HPC LF from other hydroxypropyl cellulose grades?
A: Klucel HPC LF is a low-viscosity, free-flowing grade of hydroxypropyl cellulose specifically engineered for rapid dispersion and dissolution in water without requiring heat or pre-hydration. Its optimized particle size distribution and surface treatment enhance handling and reduce dust generation compared to conventional HPC powders.
Q2: In which types of formulations is Klucel HPC LF most commonly used?
A: Klucel HPC LF is widely employed in oral solid dosage forms (e.g., immediate- and sustained-release tablets), topical gels, ophthalmic solutions, and personal care products such as hair styling gels and skin moisturizers—where clarity, film-forming capability, and non-ionic compatibility are critical.
Q3: How does Klucel HPC LF perform in acidic or alkaline environments?
A: As a non-ionic cellulose ether, Klucel HPC LF maintains good solution stability across a broad pH range (approximately pH 2–11), with minimal viscosity change under typical formulation conditions. It is not susceptible to hydrolysis at mild acidic or neutral pH, though prolonged exposure to strongly alkaline conditions at elevated temperature may affect performance.
Q4: Can Klucel HPC LF be used in combination with other polymers or excipients?
A: Yes—Klucel HPC LF is generally compatible with common pharmaceutical and cosmetic excipients, including sugars, surfactants, preservatives, and other cellulose derivatives. Synergistic effects have been observed with certain natural gums and synthetic thickeners, though compatibility should be verified experimentally for each specific formulation.
Contact With Us:
E-mail: wangxingqiang@ericwchem.com
Have a Questions? Call Us:
Add:
Building A1, Jiete Industrial Park, Huangpu District, Guangzhou City, Guangdong Province, China
