Nonionic triblock copolymer based on poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) architecture.
High molecular weight (approx. 10,300 g/mol) offering enhanced steric stabilization and viscosity-modifying capability.
Excellent water solubility across a broad temperature range with reversible thermogelling behavior above its cloud point.
Low toxicity profile and regulatory acceptance for use in pharmaceutical, cosmetic, and food-contact applications.
Effective emulsifier and solubilizer for hydrophobic actives, oils, and fragrances in aqueous formulations.
Stabilizer and viscosity enhancer in topical pharmaceutical gels and ointments.
Carrier and solubilizing agent for poorly water-soluble APIs in oral liquid formulations.
Emulsifier in high-performance personal care products including cleansing creams and moisturizers.
Template and structure-directing agent in nanoparticle synthesis and mesoporous material preparation.
Dispersant and wetting aid in agrochemical suspension concentrates (SCs) and microemulsions (MEs).
| Chemical Type | Nonionic triblock copolymer (PEO-PPO-PEO) |
| Product Form | White to off-white flake or granular solid |
| Appearance | Free-flowing, hygroscopic solid |
| Cloud Point (1% aqueous solution) | ~25–28 °C |
| pH (1% aqueous solution) | 5.0–7.0 |
| Solubility | Freely soluble in water; soluble in polar organic solvents (e.g., ethanol, propylene glycol) |
| Key Features | Thermoreversible gelation, steric stabilization, low CMC, non-irritating |
| Primary Applications | Pharmaceutical delivery systems, cosmetics, agrochemicals, nanomaterial synthesis |
Q1: What is the primary chemical structure and classification of Pluronic PE 10300?
A: Pluronic PE 10300 is a polyether-based nonionic surfactant composed of a hydrophobic polypropylene oxide (PPO) core flanked by hydrophilic polyethylene oxide (PEO) blocks. It belongs to the Pluronic® family of triblock copolymers with a PEO–PPO–PEO architecture, designed for balanced surface activity and thermoresponsive behavior in aqueous systems.
Q2: In which types of industrial formulations is Pluronic PE 10300 most commonly applied?
A: It is widely used in agrochemical formulations (e.g., emulsifiable concentrates and suspension concentrates), personal care products (as a solubilizer and viscosity modifier), and industrial cleaning systems—particularly where stable microemulsions, low-foaming performance, or temperature-triggered phase behavior is required.
Q3: How does Pluronic PE 10300 behave with respect to cloud point and temperature sensitivity?
A: As a thermoresponsive surfactant, Pluronic PE 10300 exhibits a distinct cloud point in aqueous solution—typically observed between 35 °C and 50 °C depending on concentration and ionic strength. This reversible phase transition enables applications such as temperature-controlled solubilization, triggered release, or in situ viscosity modulation.
Q4: Is Pluronic PE 10300 compatible with common electrolytes and other surfactants in formulation blends?
A: Yes—it demonstrates good compatibility with anionic and cationic surfactants in many cases, and tolerates moderate levels of inorganic salts. However, high electrolyte concentrations may lower its cloud point or affect micellization efficiency; formulation screening is recommended to confirm stability under specific conditions.
Q5: What are typical handling and storage recommendations for Pluronic PE 10300?
A: Store in original, tightly sealed containers at temperatures between 5 °C and 30 °C, protected from direct sunlight and moisture. Avoid prolonged exposure to freezing conditions, as crystallization may occur and require gentle warming to redissolve without degradation. Always refer to the Safety Data Sheet (SDS) for safe handling practices.
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