Eastman CA-320S NF/EP Cellulose Acetate Butyrate

Features Of Eastman CA-320S NF/EP Cellulose Acetate Butyrate

1. Dual Pharmacopoeia Compliance - Meets NF/EP standards, manufactured under cGMP, pharm-grade quality guaranteed

2. Low Acetyl & High Hydroxyl - Low acetyl and high hydroxyl content, suitable for preparing drug controlled-release membranes

3. Precise Controlled-Release - Regulates drug release rate, achieves long-acting and stable drug delivery, enhances efficacy

4. Efficient Drug Taste Masking - Effectively masks unpleasant drug odors, improving patient medication compliance

5. Easy Granular Processing - Good fluidity of granular form, easy to disperse and prepare, convenient for formulation processing

Typical Applications Of Eastman CA-320S NF/EP Cellulose Acetate Butyrate

1. Osmotic Controlled-Release Formulations - Used as membrane material for osmotic pump controlled-release formulations to precisely regulate drug release rhythm

2. Drug Taste Masking Coating - Used for coating oral drug particles/tablets to mask bitter and other unpleasant odors

3. Sustained-Release Microcapsule Matrix - Used as matrix for drug microcapsule preparation to prolong drug action time

4. Pharmaceutical Membrane Preparation - Used for preparing pharmaceutical sustained-release membranes and isolation membranes to improve formulation stability

Specifications Of Eastman CA-320S NF/EP Cellulose Acetate Butyrate

Eastman CA-320S NF/EP Cellulose Acetate Butyrate – Frequently Asked Questions (FAQ)

Q1: What are the key regulatory designations for Eastman CA-320S NF/EP?

A: Eastman CA-320S NF/EP is compliant with the United States Pharmacopeia (USP) and European Pharmacopoeia (Ph. Eur.) monographs for Cellulose Acetate Butyrate, and is designated as NF (National Formulary) and EP (European Pharmacopoeia) grade—indicating suitability for pharmaceutical and medical device applications where compendial compliance is required.

Q2: How does CA-320S NF/EP differ from standard cellulose acetate butyrate grades?

A: CA-320S NF/EP is specifically purified and controlled to meet stringent pharmacopoeial requirements for residual solvents, heavy metals, and microbial limits. It also features a consistent molecular weight distribution and optimized butyryl/acetyl substitution ratio to support reproducible film formation and compatibility in sensitive formulations such as oral solid dosage coatings and medical device binders.

Q3: In which types of pharmaceutical formulations is CA-320S NF/EP most commonly used?

A: It is widely employed as a functional film-coating polymer for immediate- and modified-release tablets and capsules, and as a binder or matrix former in hot-melt extrusion and direct compression applications. Its balanced solubility profile supports use in both organic and aqueous-based coating systems.

Q4: Is CA-320S NF/EP compatible with common plasticizers used in pharmaceutical film coatings?

A: Yes—it demonstrates good compatibility with widely accepted pharmaceutical plasticizers such as triethyl citrate, acetyl tributyl citrate, and polyethylene glycol, enabling formulation flexibility while maintaining film integrity and mechanical performance across storage conditions.

Q5: What handling precautions should be observed during processing?

A: As with other hygroscopic polymers, CA-320S NF/EP should be stored under dry conditions and may benefit from pre-drying prior to high-shear processing or solvent-based operations. Avoid prolonged exposure to high humidity to prevent viscosity variability or agglomeration during dissolution or dispersion.