Enteric polymer with pH-dependent solubility—insoluble below pH 5.0 and rapidly dissolves above pH 5.5.
Enables robust amorphous solid dispersion (ASD) stabilization for poorly water-soluble active pharmaceutical ingredients (APIs).
Offers excellent film-forming capability and thermal stability during hot-melt extrusion (HME) processing.
Provides high glass transition temperature (Tg) to enhance physical stability of spray-dried dispersions (SDDs).
Complies with USP/NF, EP, and JP monographs for pharmaceutical excipients.
Amorphous solid dispersions (ASDs) for oral dosage forms including tablets and capsules.
Enteric-coated granules and pellets for targeted intestinal release.
Stabilizer in hot-melt extrusion (HME) formulations for bioavailability enhancement.
Spray-dried dispersion (SDD) matrix for high-potency low-solubility drug substances.
Functional coating layer in controlled-release multiparticulate systems.
| Chemical Type | Cellulosic enteric polymer (HPMC-AS) |
| Product Form | White to off-white free-flowing powder |
| Appearance | Free-flowing granular or powdered solid |
| Primary Applications | Pharmaceutical amorphous solid dispersions and enteric coatings |
| Key Features | pH-dependent solubility, high Tg, excellent ASD stabilization |
| Benefits | Enhanced API solubility, improved chemical/physical stability, regulatory compliance |
| Regulatory Status | USP/NF, Ph. Eur., JP listed; DMF available |
| Storage Conditions | Store in original container at 15–30 °C, protect from moisture |
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