Guangzhou Eric Wei Chemical Co., Ltd.
Guangzhou Eric Wei Chemical Co., Ltd.

Ashland Aquasolve H Hydroxypropyl Methylcellulose Acetate Succinate

Ashland Aquasolve H Hydroxypropyl Methylcellulose Acetate Succinate is a pH-responsive, film-forming polymer designed for enteric protection and controlled release in oral solid dosage forms. It dissolves above pH 5.5, enhances bioavailability of poorly soluble drugs, and offers excellent tablet coating and granulation performance. Widely used in pharmaceutical formulations requiring gastric resistance and intestinal targeting.
  • ashland aquasolve h hydroxypropyl methylcellulose acetate succinate_99c15137
  • ashland aquasolve h hydroxypropyl methylcellulose acetate succinate_99c15137

Features Of Ashland Aquasolve H Hydroxypropyl Methylcellulose Acetate Succinate

  1. Enteric polymer with pH-dependent solubility—insoluble below pH 5.0 and rapidly dissolves above pH 5.5.

  2. Enables robust amorphous solid dispersion (ASD) stabilization for poorly water-soluble active pharmaceutical ingredients (APIs).

  3. Offers excellent film-forming capability and thermal stability during hot-melt extrusion (HME) processing.

  4. Provides high glass transition temperature (Tg) to enhance physical stability of spray-dried dispersions (SDDs).

  5. Complies with USP/NF, EP, and JP monographs for pharmaceutical excipients.

Typical Applications Of Ashland Aquasolve H Hydroxypropyl Methylcellulose Acetate Succinate

  1. Amorphous solid dispersions (ASDs) for oral dosage forms including tablets and capsules.

  2. Enteric-coated granules and pellets for targeted intestinal release.

  3. Stabilizer in hot-melt extrusion (HME) formulations for bioavailability enhancement.

  4. Spray-dried dispersion (SDD) matrix for high-potency low-solubility drug substances.

  5. Functional coating layer in controlled-release multiparticulate systems.

Specifications Of Ashland Aquasolve H Hydroxypropyl Methylcellulose Acetate Succinate

Chemical TypeCellulosic enteric polymer (HPMC-AS)
Product FormWhite to off-white free-flowing powder
AppearanceFree-flowing granular or powdered solid
Primary ApplicationsPharmaceutical amorphous solid dispersions and enteric coatings
Key FeaturespH-dependent solubility, high Tg, excellent ASD stabilization
BenefitsEnhanced API solubility, improved chemical/physical stability, regulatory compliance
Regulatory StatusUSP/NF, Ph. Eur., JP listed; DMF available
Storage ConditionsStore in original container at 15–30 °C, protect from moisture


Get in Touch with ERICW
Let competitive chemical materials go global.

Your Name *

Your Email *

Your Phone

Country

Your Message *