Low-viscosity grade optimized for high-shear processing and rapid dissolution in cold water.
Excellent film-forming capability with good flexibility and clarity in dried films.
Non-ionic, pH-stable polymer compatible with a broad range of active ingredients and excipients.
USP/NF and EP/JP compliant, suitable for pharmaceutical and personal care applications.
Free-flowing powder with consistent batch-to-batch performance and low dust generation.
Oral immediate-release tablet binders and dry granulation aids.
Viscosity control agent in liquid and semi-solid pharmaceutical formulations.
Film-coating component for tablets and capsules requiring smooth, transparent coatings.
Thickener and stabilizer in rinse-off and leave-on personal care products (e.g., shampoos, gels, lotions).
Binding and suspending agent in veterinary oral suspensions and topical solutions.
| Chemical Type | Hydroxypropyl cellulose (HPC) |
| Product Form | Free-flowing white to off-white powder |
| Appearance | Odorless, fine particulate powder |
| Primary Applications | Pharmaceutical solid dosage forms, personal care rheology modifiers |
| Key Features | Cold-water soluble, non-ionic, thermally reversible gelation |
| Benefits | Enhances tablet hardness, improves suspension stability, enables clear aqueous gels |
| Regulatory Status | USP/NF, EP, JP, FDA GRAS (for food contact), ISO 9001 manufactured |
| Solubility | Freely soluble in water; soluble in methanol, ethanol (≤30%), and dichloromethane |
Q1: What is the primary functional role of Klucel LF in pharmaceutical and personal care formulations?
A: Klucel LF functions primarily as a non-ionic, water-soluble thickener, binder, and suspension aid. It provides excellent rheology control, enhances viscosity at low concentrations, and contributes to improved stability and texture without interfering with active ingredients or preservative systems.
Q2: How does Klucel LF differ from other grades of hydroxypropyl cellulose (HPC), such as Klucel EX or GF?
A: Klucel LF is a low molecular weight grade of HPC, offering faster dissolution, lower solution viscosity, and enhanced compatibility with high-alcohol or low-water systems—making it especially suitable for clear gels, sprayable formulations, and rapid-dissolving oral dosage forms. Higher molecular weight grades like EX or GF deliver greater thickening power but require more energy for dispersion and may impart higher stringiness.
Q3: Is Klucel LF compatible with common cosmetic actives and preservatives?
A: Yes, Klucel LF demonstrates broad compatibility with surfactants, emollients, botanical extracts, peptides, and widely used preservative systems—including parabens, phenoxyethanol, and sodium benzoate—under typical pH and temperature conditions encountered in leave-on and rinse-off products.
Q4: Can Klucel LF be used in hot-melt extrusion or direct compression tablet manufacturing?
A: While Klucel LF is not typically selected as a primary binder for hot-melt extrusion due to its relatively low thermal stability onset, it is well-suited for direct compression applications where low-dose binding, improved flowability, and rapid disintegration are desired—particularly in combination with other excipients.
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