Dow CARBOWAX PEG 3350 (Polyethylene Glycol 3350) is a versatile mild polymer in Dow's CARBOWAX product line. Designed for daily chemical care, industrial cleaning, rubber and plastic processing and other diverse systems, it is a non-toxic and non-irritating white flaky solid polymer with excellent water solubility and broad-spectrum compatibility
Mild, Safe & Non-Toxic - Non-toxic and non-irritating, excellent biocompatibility, suitable for sensitive application scenarios
Efficient Water Solubility & Compatibility - Easily soluble in water and polar solvents, broad-spectrum compatible with multiple components, strong formulation adaptability
Balanced Function Integration - With multiple functions of lubrication, dispersion and thickening, simplifying formulation systems
Stable Batch Consistency - Strong chemical stability, uniform batch performance, ensuring stable quality of end products
Daily Chemical Care Field - Used as moisturizer in skin care products, conditioner in shampoos and oral care products to improve product mildness and smoothness
Industrial Cleaning Field - Used as mild cleaning auxiliary in fabric detergents and metal cleaners to enhance decontamination and dispersion effects
Rubber & Plastic Processing Field - Used as lubricant and release agent in rubber and plastic processing to improve processing efficiency and product surface smoothness
Textile & Papermaking Field - Applied in textile softening finishing and papermaking sizing agent to improve product hand feel and strength
| Chemical Name | Polyethylene Glycol 3350 |
| English Common Name | PEG 3350 |
| CAS No. | 25322-68-3 |
| Molecular Formula | HO-(CH₂CH₂O)ₙ-H (n≈75-85) |
| Molecular Weight | 3000 - 3700 |
| Physical Form | White flaky solid |
| Melting Point | 50 - 56 ℃ |
| Boiling Point | > 250 ℃ (Decomposition) |
| Flash Point (Closed Cup) | > 270 ℃ |
Q1: What is the primary functional role of CARBOWAX PEG 3350 in pharmaceutical and personal care formulations?
A: CARBOWAX PEG 3350 serves primarily as a water-soluble binder, solubilizer, and viscosity modifier. It enhances the dissolution rate of active ingredients, improves tablet disintegration, and contributes to uniform dispersion in liquid and semi-solid systems such as ointments, gels, and oral suspensions.
Q2: How does CARBOWAX PEG 3350 differ from lower- or higher-molecular-weight PEG grades in terms of physical behavior?
A: With an average molecular weight of approximately 3350 Da, CARBOWAX PEG 3350 is a semi-crystalline, low-melting solid at room temperature—offering a favorable balance between solubility, melt processability, and film-forming capability. It melts more readily than higher-MW PEGs (e.g., PEG 6000) and provides greater viscosity and binding strength than lower-MW grades (e.g., PEG 400 or PEG 1000).
Q3: Is CARBOWAX PEG 3350 suitable for use in hot-melt extrusion (HME) processes?
A: Yes—it is commonly selected for HME applications due to its relatively low melting point (~52–57 °C), thermal stability under typical processing conditions, and ability to act as both a plasticizer and matrix former. Its compatibility with APIs and polymers supports robust amorphous solid dispersion formation.
Q4: Can CARBOWAX PEG 3350 be used in food-contact or pharmaceutical-grade applications?
A: Dow manufactures CARBOWAX PEG 3350 to meet USP/NF and Ph. Eur. monograph requirements for Polyethylene Glycol 3350, supporting its use in pharmaceutical dosage forms and certain food-contact applications where regulatory compliance and quality consistency are required. Always verify conformance with current lot-specific documentation.
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