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Ashland Benecel HPMC 2208K K4M is a high-quality direct compression (DC) grade hydroxypropyl methylcellulose in the Benecel 2208K series. Custom-designed for direct compression production of oral controlled-release tablets, it meets stringent international pharmacopoeia standards, featuring excellent compressibility and flowability
Excellent DC Adaptation - Designed for direct compression process, with excellent flowability and compressibility, simplifying production workflow
Precise Controlled-Release Regulation - Forms gel matrix structure, stably regulating drug release for long-acting administration
Efficient Binding & Molding - Excellent binding performance, ensuring uniform tablet hardness and reducing friability risk
Broad Process Compatibility - Suitable for diverse drug formulations, highly compatible with common excipients, flexible in application
Controlled-Release Tablet Preparation - Used for direct compression of oral sustained-release and controlled-release tablets to construct gel matrix system
Compound Formulation Production - Used in preparation of multi-component compound tablets to ensure component uniformity and release stability
Low-Dose Drug Molding - Used for direct compression of low-dose drug tablets to improve content uniformity and production efficiency
Modified Formulation R&D - Used in drug formulation modification to optimize release profile and patient compliance
| Brand | Ashland (USA) |
| Chemical Type | Hydroxypropyl Methylcellulose (HPMC) Type 2208, non-ionic cellulose ether |
| Physical Form | White to off-white free-flowing powder |
| Core Characteristics | DC adaptation, precise controlled-release, efficient binding |
| CAS Number | 9004-65-3 |
| Weight-Average Molecular Weight | 400,000 |
| Viscosity (2% aqueous solution) | 2700 - 5040 mPa·s |
Q1: What is the primary functional role of Benecel HPMC 2208K K4M in aqueous formulations?
A: Benecel HPMC 2208K K4M functions primarily as a water-soluble thickener and rheology modifier, providing pseudoplastic flow behavior, improved suspension stability, and enhanced film-forming capability in cold-water-dissolving systems.
Q2: How does the K4M grade designation relate to its viscosity performance?
A: The “K4M” designation indicates a medium-viscosity grade within the Benecel HPMC product line, with nominal viscosity measured in a 2% aqueous solution at 20°C. It delivers balanced thickening efficiency and ease of hydration suitable for applications requiring moderate structural integrity without excessive gel strength.
Q3: Is Benecel HPMC 2208K K4M compatible with common preservatives and electrolytes used in industrial and pharmaceutical formulations?
A: Yes — it exhibits good compatibility with widely used antimicrobial agents and demonstrates reasonable tolerance to low-to-moderate levels of salts, though high electrolyte concentrations may reduce solution viscosity and affect clarity; formulation optimization is recommended for challenging ionic environments.
Q4: What are typical handling considerations during dissolution to avoid clumping or incomplete dispersion?
A: To ensure efficient dispersion, it is recommended to pre-blend the powder with dry excipients (e.g., sugars or fillers) or disperse gradually under high-shear mixing in cold water; direct addition to hot water should be avoided to prevent surface gelation and agglomeration.
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